Porphyrins (Urine)

Testing Laboratory

Auckland Te Toka Tumai | Auckland Hospital

Department

Chemical Pathology

Delphic Registration Code (Alpha Code)

UPOR (urine)

Test Code (Numeric Code)

746

Laboratory Handling

Transport

URGENT - Must be hand delivered at all times from all locations - Must be protected from light - If after hours bring sample to the attention of Automation staff.

Laboratory

LabPLUS Special Chemistry

Sample Stability

36 hours at 2-8°C.
Up to 8 months frozen.

Synonyms

PBG, Porphobilinogen, Porphyrias, Porphyrins

Turnaround Time

2 days

PBG screens will be performed within 1-2 days. Urine, faecal, and blood porphyrin screens will be performed within 1-2 weeks. For samples with a raised screen, a porphyrin profile will be performed within the next 3 weeks.

Specimen Type

  • Urine

Specimen Requirements

Tube/Container Type:

Preferred
  • Please refer to Additional Information below
  • Specimen Container
Preferred Sample Volume (ml)

10

Paediatric Specimen Requirements

Tube/Container Type:

Preferred
  • Please refer to Additional Information below
  • Specimen Container
Preferred Sample Volume (ml)

10

Pre-testing Requirements

The patient should refrain from taking Vitamin B supplements a day before collection because riboflavin (Vitamin B2) interferes with the urine porphyrin test. However, PBG is unaffected and collection in acute presentations should proceed regardless of vitamin intake, so as not to miss a possible diagnosis of acute porphyria

Additional Specimen Information

As porphyrins are light sensitive, all specimens must be kept in the dark; usually this is done by wrapping the specimen in foil.

Porphyrin profile (HPLC analysis) will be done automatically if the total porphyrins are increased.

Note that this urine porphyrin screen qualitatively assesses PBG (as positive or negative). If quantitation is required, please request "porphobilinogen quantitation", though this test is rarely clinically indicated.

Last updated: 31/08/2026